Key result
In patients with type 2 diabetes mellitus, higher serum omentin levels were associated with an increased prevalence of cardiac autonomic neuropathy.
Why the study?
Are serum omentin levels associated with cardiac autonomic neuropathy and other vascular complications in patients with type 2 diabetes mellitus?
Cross-Sectional (n=97)
No
Are serum omentin levels associated with cardiac autonomic neuropathy and other vascular complications in patients with type 2 diabetes mellitus?
Higher serum omentin levels are independently associated with cardiac autonomic neuropathy and increased arterial stiffness in patients with type 2 diabetes.
Answers are grounded in this paper and cite their sources.
Higher omentin may flag CAN risk in T2DM but should not change practice; leaves open its causal role or biomarker utility.
BACKGROUND: Whereas a few studies have reported associations of serum omentin levels with subclinical atherosclerosis in patients with diabetes, little information is available with respect to the associations of serum omentin levels and diabetic microvascular complications. The aim of this study was to investigate the relationships of serum omentin levels and vascular complications including cardiac autonomic neuropathy (CAN) in patients with type 2 diabetes mellitus (T2DM). METHODS: We recruited 97 patients who evaluated complications of diabetes. CAN was assessed by five standard cardiovascular reflex tests according to Ewing's protocol. Diabetic nephropathy (DN), retinopathy (DR), and peripheral neuropathy (DPN) were evaluated. Serum omentin levels were assessed by ELISA. Atherosclerotic burden was evaluated by measuring the brachial-ankle pulse wave velocity (baPWV) and ankle brachial index (ABI). RESULTS: The prevalence of CAN increased borderline significantly across the omentin tertiles (p = 0.05) and CAN point increased significantly and progressively across the omentin tertiles (p = 0.013). The prevalence of other microvascular complications (DPN, DN, and DR) did not differ among omentin tertiles. The mean levels of baPWV also increased significantly and progressively across the omentin tertiles (p = 0.002). Serum omentin levels were significantly positively correlated with CAN point (p = 0.004) and borderline significantly correlated with baPWV (p = 0.05) after multivariate adjustment. Regarding linear regression analysis for CAN point, univariate regression analysis demonstrated that CAN point associated with omentin, diastolic blood pressure (DBP) and hsCRP. Multiple regression analysis revealed that omentin levels, together DBP and baPWV correlated with CAN point. This present study suggests that serum omentin levels may be independently associate with CAN in patients with T2DM.
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Jung et al. (2015) conducted a cross-sectional in Type 2 diabetes mellitus (n=97). Serum omentin levels vs. Lower tertiles of serum omentin was evaluated on Prevalence of cardiac autonomic neuropathy (CAN) (p=0.017). In patients with type 2 diabetes mellitus, higher serum omentin levels were associated with an increased prevalence of cardiac autonomic neuropathy.
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