Key result
Type 1 diabetes in adolescents is linked to ~30% lower omentin levels and reduced HRV.
Why the study?
Is omentin associated with cardiac autonomic neuropathy and metabolic parameters in patients with type 1 diabetes?
Cross-Sectional (n=92)
No
Is omentin associated with cardiac autonomic neuropathy and metabolic parameters in patients with type 1 diabetes?
In type 1 diabetes, reduced omentin levels are associated with cardiac autonomic neuropathy and altered glucose metabolism.
Answers are grounded in this paper and cite their sources.
Lower omentin may signal autonomic neuropathy risk in type 1 diabetes adolescents; leaves open predictive value and therapeutic role pending prospective studies.
AIM: To evaluate cardiac affection in type 1 diabetes in relation to Omentin. PATIENTS AND METHODS: Sixty two diabetics and 30 volunteer of the same age and sex were included as a control group. Blood sample was taken for assessment of omentin and oxidized low density lipoprotein (OxLDL), glycosylated hemoglobin (HbA1) and lipid profile. Urine sample was taken for assessment of albumin/creatinine ratio. 24 hour holter was also done. T-test, simple correlation followed by stepwise multiple regression analysis was used for analysis of data. RESULTS: Parameters of 24 hour holter were significantly lower in diabetics. Omentin was significantly lower, while OxLDL were significantly higher than controls. RMSSD, ST deviation and OxLDL were the parameters related to omentin by stepwise multiple regression analysis in diabetics. CONCLUSION: Diabetic patients had a cardiac autonomic neuropathy. A significant reduction of omentin and elevation OxLDL imply that they influence glucose metabolism in type 1 diabetes. Omentin had a significant relation to 24 hr holter which may reflect its role in cardiac affection. Omentin and OxLDL had a role in renal affection.
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Dayem et al. (2015) conducted a cross-sectional in Type 1 Diabetes Mellitus and Cardiac Autonomic Neuropathy (n=92). Type 1 Diabetes Mellitus (and circulating Omentin levels) vs. Healthy age- and sex-matched controls was evaluated on Serum Omentin level (ng/ml) (p=0.0001). Adolescents with type 1 diabetes had lower serum omentin levels than healthy controls, which correlated with reduced heart rate variability.
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