Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
March 1, 1987Circulation ResearchOpen Access

Centripetal spread of arterial collateral endothelial cell hyperplasia after renal artery stenosis in the rat.

View Full Paper
Ask AI
Bookmark
Share

Key result

Renal artery stenosis in rats induces a progressive centripetal gradient in endothelial cell labelling.

  • P<0.01

Population

Rat model of renal artery stenosis (periureteric collateral arterial supply)

Design

Preclinical

Follow-up

Serial studies starting at 24 to 48 hours

Authors

NHNorman K. HollenbergTOT Odori

Discussion

Loading...

Member takes

Overview

Suggests ischemia drives collateral growth after occlusion; leaves open translation to human revascularization strategies.

Structured PICO

P
Population
Rats subjected to renal artery stenosis to study collateral arterial growth.
I
Intervention
Renal artery stenosis
O
Outcome
Endothelial cell labelling with tritiated thymidine (index of collateral arterial growth)surrogate

Main Result

p-value: p=<0.01

Collateral arterial growth following major artery occlusion appears to be driven by downstream ischemic events rather than luminal blood flow, spreading centripetally from the ischemic zone.

Limitations

  • The mechanism responsible for the centripetal spread remains speculative.
  • Mechanism responsible for the centripetal spread remains speculative

Cite This Study

Hollenberg et al. (1987) studied Renal artery stenosis. Renal artery stenosis was evaluated on Endothelial cell labelling with tritiated thymidine (p=<0.01). Renal artery stenosis in rats induced a progressive, time-related centripetal gradient in endothelial cell tritiated thymidine labelling (p<0.01).

synapsesocial.com/papers/6aa0bc15b59423aee28d3135https://doi.org/10.1161/01.res.60.3.398
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Increase in collateral arterial endothelial cell proliferation induced by captopril after renal artery stenosis in the rat.1983 · 13 citations
  2. 2Time course of increased collateral arterial and venous endothelial cell turnover after renal artery stenosis in the rat.1979 · 28 citations
  3. 3Neovascular responses induced by cultured aortic endothelial cells1983 · 68 citations
  4. 4Vascular wall growth control: the role of the endothelium.1981 · 174 citations