Key result
Captopril administration enhanced the endothelial cell proliferative response in both frequency and degree following renal artery stenosis in rats.
Why the study?
Does captopril enhance collateral arterial endothelial cell proliferation following renal artery stenosis in rats?
Population
70 rats with induced renal artery stenosis
Comparison
Captopril administration vs No captopril
Design
Preclinical, coded reading of endothelial cell turnover
Follow-up
5 days
Authors
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Should not change clinical practice; extends preclinical data on captopril and endothelial proliferation after renal artery stenosis.
Does captopril enhance collateral arterial endothelial cell proliferation following renal artery stenosis in rats?
In a rat model of renal artery stenosis, captopril unexpectedly enhanced collateral arterial endothelial cell proliferation, suggesting a mechanism independent of simple blood pressure reduction.
Odori et al. (1983) studied Renal artery stenosis (n=70). Captopril was evaluated on Endothelial cell turnover. Captopril administration enhanced the endothelial cell proliferative response in both frequency and degree following renal artery stenosis in rats.
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