Key result
Initial left atrial peak late negative strain rate significantly predicted major adverse cardiac events in suspected myocarditis (HR 10.389; 95% CI 2.250-47.977; p=0.003).
Why the study?
The study aimed to assess the variation in left atrial and biventricular strain and its prognostic value during the course of suspected myocarditis.
Does cardiac magnetic resonance (CMR) left atrial and biventricular strain analysis predict major adverse cardiac events in patients with suspected myocarditis?
Cohort (n=55)
Does cardiac magnetic resonance (CMR) left atrial and biventricular strain analysis predict major adverse cardiac events in patients with suspected myocarditis?
Hazard Ratio: 10.389 (95% CI 2.25–47.977)
p-value: p=0.003
Left atrial strain analysis by CMR, specifically the initial LA peak's late negative strain rate, may serve as a powerful independent predictor of major adverse cardiac events in patients with suspected myocarditis.
LA SRa may aid MACE risk stratification in suspected myocarditis; hypothesis-generating and should not yet change practice.
To assess the variation in left atrial (LA) and biventricular strain and its prognostic value in the course of suspected myocarditis, this retrospective study included 55 patients with clinically suspected myocarditis who underwent cardiac magnetic resonance (CMR) examinations at baseline and follow-up periods. Cine images were used for feature tracking analysis. Paired Student’s t test, McNemar’s test, and Cox proportional hazard regression were used for statistical analysis. The LA total emptying fraction was the only functional index that showed a statistically significant improvement. The initial LA peak’s late negative strain rate (SRa) was the only parameter with a significant predictive power of major adverse cardiac events under univariable (hazard ratio [HR] 2.396, 95% confidence interval [CI] 1.044–5.498, p = 0.039) and multivariable Cox survival analysis when adjusted by LA strain parameters (HR 5.072, 95% CI 1.478–17.404, p = 0.010), LA strain and functional parameters (HR 7.197, 95% CI 1.679–30.846, p = 0.008), and LA and biventricular strain and functional parameters (HR 10.389, 95% CI 2.250–47.977, p = 0.003). Thus, our findings indicate that CMR strain is useful for monitoring LA and ventricular function in suspected myocarditis, that LA function may recover preceding ventricular function changes, and that LA strain may serve as an incremental tool to predict adverse outcomes.
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Chen et al. (2023) conducted a cohort in suspected myocarditis (n=55). Initial left atrial peak late negative strain rate (SRa) was evaluated on Major adverse cardiac events (HR 10.389, 95% CI 2.250-47.977, p=0.003). Initial left atrial peak late negative strain rate significantly predicted major adverse cardiac events in suspected myocarditis (HR 10.389; 95% CI 2.250-47.977; p=0.003).
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