Key result
In isolated rat hepatocytes, changes in transmembrane electrical potential difference, mediated by pH-sensitive potassium conductance, play a central role in regulating intracellular pH through effects on electrogenic Na+/HCO3- cotransport.
Population
Hepatocytes (individual cells)
Comparison
Exposure to 50 mM K+, NH4Cl, 10% CO2, Ba2+, or… vs Absence of HCO3-
Design
Preclinical
Authors
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Does not support clinical translation in hepatology; leaves open whether voltage-dependent pH regulation operates in vivo or human hepatocytes.
In hepatocytes, changes in transmembrane electrical potential difference, mediated by pH-sensitive K+ conductance, play a central role in regulating intracellular pH through effects on electrogenic Na+/HCO3- cotransport.
Fitz et al. (1992) studied this question. Membrane depolarization and pH alterations vs. Absence of HCO3- was evaluated on Intracellular pH (pHi) and membrane potential difference (PD). In isolated rat hepatocytes, changes in transmembrane electrical potential difference, mediated by pH-sensitive potassium conductance, play a central role in regulating intracellular pH through effects on electrogenic Na+/HCO3- cotransport.
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