Effect of pH on membrane potential and K+ conductance in cultured rat hepatocytes

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Population

Cultured rat hepatocytes in primary culture

Comparison

Changes in extracellular and intracellular pH… vs Baseline conditions

Design

Preclinical

Authors

Discussion

Requires caution before clinical translation in liver disease; extends rat data on pHi-K+ links but leaves open human relevance.

Population

Cultured rat hepatocytes in primary culture

Intervention

Changes in extracellular (pHo) and intracellular (pHi) pH, exposure to 1 mM Ba2+, exposure to butyrate, or withdrawal of NH4+

Comparator

Baseline conditions (e.g., presence of 25 mM HCO3-)

Outcome

Membrane potential difference (PD) and cell conductance (gcell)surrogate

The membrane potential of rat hepatocytes is strongly influenced by intracellular pH, mediated through changes in plasma membrane K+ conductance.

Fitz et al. (1989) studied this question.

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