Population
Rat hepatocytes in confluent primary cultures
Comparison
Reducing extracellular osmolarity by 80 mosmol/l vs Normosmotic solutions
Design
Preclinical
Follow-up
5 minutes (time of maximum hyperpolarization)
Authors
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Suggests osmotic modulation of rat hepatocyte K+ conductance; leaves open relevance to human liver physiology.
Reducing extracellular osmolarity transiently increases K+ conductance and hyperpolarizes cell membranes in rat hepatocytes.
Wehner et al. (1992) studied this question.
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