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As a last-resort antimicrobial agent to treat serious infections, the emergence and spread of tigecycline resistance in Enterobacteriaceae and Acinetobacter have raised global concerns. Multiple mechanisms mediate tigecycline resistance in Enterobacteriaceae , such as the monooxygenase Tet(X), mutations in Tet proteins, and overexpression of efflux pumps.
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Wang et al. (2021) studied this question.
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