Key result
The dynamic arterial baroreflex was preserved in rabbits with rapid pacing-induced heart failure, with similar transfer function gain compared to controls over 0.04-0.4 Hz.
In a rabbit model, excessive sympathetic nerve activity in heart failure appears unrelated to impaired dynamic arterial baroreflex, which remains preserved possibly due to impaired cardiopulmonary baroreflex.
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Preserved dynamic baroreflex in rabbit HF model; leaves open cardiopulmonary baroreflex role in sympathetic overdrive pending human data.
Masaki et al. (1994) studied Heart failure (n=18). Rapid pacing-induced heart failure vs. Control rabbits was evaluated on Gain of the transfer function from aortic pressure to renal nerve activity over 0.04-0.4 Hz. The dynamic arterial baroreflex was preserved in rabbits with rapid pacing-induced heart failure, with similar transfer function gain compared to controls over 0.04-0.4 Hz.
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