Key result
A second course of OKT3 prophylaxis in heart transplant recipients resulted in rapid depletion of circulating functional T cells despite the presence of anti-OKT3 antibodies from the first course.
Why the study?
Does a second course of OKT3 prophylaxis deplete peripheral T cells despite induced anti-OKT3 antibodies in heart transplant recipients?
Population
24 heart transplant recipients
Design
Cohort
Authors
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May permit repeat OKT3 despite antibodies; hypothesis-generating for outcomes, requires prospective validation before practice change.
Cohort (n=24)
Does a second course of OKT3 prophylaxis deplete peripheral T cells despite induced anti-OKT3 antibodies in heart transplant recipients?
Induced anti-OKT3 antibodies from a first course of OKT3 prophylaxis do not prevent the depletion of peripheral T cells during a second course in heart transplant patients.
Hesse et al. (1991) conducted a cohort in Heart transplant (n=24). OKT3 prophylaxis was evaluated on T cell depletion and anti-OKT3 antibody levels. A second course of OKT3 prophylaxis in heart transplant recipients resulted in rapid depletion of circulating functional T cells despite the presence of anti-OKT3 antibodies from the first course.
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