Why the study?
Is OKT3 sensitization associated with the development of vascular rejection in cardiac transplant patients receiving OKT3 prophylaxis?
Population
20 cardiac transplant patients receiving 14- or 21-day rejection prophylaxis with OKT3
Comparison
14- or 21-day rejection prophylaxis with OKT3 vs Patients without OKT3 sensitization, or 14-day…
Design
Cohort
Authors
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OKT3 sensitization may signal higher vascular rejection risk in cardiac transplant recipients; leaves open whether regimen changes improve survival.
Is OKT3 sensitization associated with the development of vascular rejection in cardiac transplant patients receiving OKT3 prophylaxis?
In cardiac transplant patients, OKT3 sensitization during prophylaxis is strongly associated with vascular rejection and significantly worse allograft and patient survival, particularly with prolonged 21-day regimens.
Hammond et al. (1990) studied this question.
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