Key result
Epidural 0.5% levobupivacaine showed no significant difference compared to 0.5% bupivacaine in onset and regression times of sensory and motor blockade or hemodynamics (P > 0.05).
Why the study?
Does epidural levobupivacaine provide similar anesthetic effectiveness compared to bupivacaine in patients undergoing elective hip and lower extremity operations?
RCT (n=70)
Does epidural levobupivacaine provide similar anesthetic effectiveness compared to bupivacaine in patients undergoing elective hip and lower extremity operations?
p-value: p=>0.05
Epidural levobupivacaine provides similar anesthetic effectiveness, satisfaction, and hemodynamic stability as bupivacaine for elective hip and lower extremity surgeries.
Supports levobupivacaine as potential epidural alternative for lower extremity surgery; observational data leaves equivalence open to randomized confirmation.
To compare the anesthetic effectiveness of epidural levobupivacaine and bupivacaine without adjuvant medication in patients who were to have elective operations on the lower extremities and hips. Materials and methods: This study was conducted on a total of 70 ASA I-II patients aged between 30 and 70 years, who underwent elective hip and lower extremity operations. The patients that received bupivacaine were assigned to Group B (n = 35) and those that received levobupivacaine to Group L (n = 35). Results: No statistically significant difference was found between the groups in terms of the onset and regression times of the sensory and motor blockade, time to reach dermatomes, initial analgesic requirement time, resolution time of the motor block, patient and surgeon satisfaction, heart rate, noninvasive systolic artery pressure, diastolic artery pressure, mean artery pressure, and peripheral oxygen saturation values (P > 0.05). Conclusion: Levobupivacaine could be a good alternative to bupivacaine in patients administered epidural anesthesia in elective hip and lower extremity operations in terms of hemodynamic parameters, quality of anesthesia and analgesia, patient and surgeon satisfaction, and complications.
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KARA et al. (2013) conducted an RCT in Elective hip and lower extremity operations (n=70). Epidural levobupivacaine vs. Epidural 0.5% bupivacaine was evaluated on Onset and regression times of sensory and motor blockade, time to reach dermatomes, and initial analgesic requirement time (p=>0.05). Epidural 0.5% levobupivacaine showed no significant difference compared to 0.5% bupivacaine in onset and regression times of sensory and motor blockade or hemodynamics (P > 0.05).
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