Key result
Ultrasound renal denervation reduces 24-hour ambulatory SBP by ~9 mm Hg in resistant hypertension.
Why the study?
The management of resistant hypertension remains problematic, prompting a systematic evaluation of the efficacy of endovascular ultrasound renal denervation.
Does endovascular ultrasound renal denervation reduce ambulatory systolic blood pressure in patients with resistant hypertension?
Meta-Analysis (n=183)
Does endovascular ultrasound renal denervation reduce ambulatory systolic blood pressure in patients with resistant hypertension?
Mean Difference: -9.07 (95% CI -13.78–-4.37)
p-value: p=0.0002
Endovascular ultrasound renal denervation effectively reduces 24-hour, daytime, and nighttime ambulatory systolic blood pressure in patients with resistant hypertension.
Supports ultrasound renal denervation for resistant hypertension; reinforces pooled randomized evidence.
The prevalence of hypertension (HTN) continues to increase in developing countries. The control rate of HTN is relatively low. The management of resistant HTN remains problematic. Recently, a promising new non-pharmacological technology using endovascular ultrasound renal denervation (uRDN) had shown its remarkable effect in resistant HTN patients. In this article, we pooled the currently available data concerning uRDN and conducted a meta-analysis to evaluate the efficacy of this technique systematically in patient with resistant HTN. Finally, a total of 3 studies out of 636 identified articles were retained. Compared to the blood pressure (BP) at randomization, the ambulatory systolic BP in daytime and nighttime reduced significantly after the procedure of uRDN. The reduction from baseline in 24-hour ambulatory systolic BP was 9.07 mm Hg. In conclusion, that uRDN was effective in reducing daytime and nighttime ambulatory systolic BP in resistant HTN populations. More randomized controlled trials with large scales and long-term follow-up are deserved in the future.
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Xue et al. (2023) conducted a meta-analysis in Resistant hypertension (n=183). Endovascular ultrasound renal denervation (uRDN) vs. Baseline was evaluated on Reduction from baseline in 24-hour ambulatory systolic blood pressure (MD -9.07 mm Hg, 95% CI -13.78 to -4.37, p=0.0002). Endovascular ultrasound renal denervation significantly reduced 24-hour ambulatory systolic blood pressure by 9.07 mm Hg from baseline in patients with resistant hypertension.
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