Key result
Abnormal admission troponin I is linked to higher in-hospital mortality in COVID-19 patients.
Why the study?
The study was conducted to describe troponin I levels in COVID-19 patients and evaluate its role as a cardiac biomarker in predicting in-hospital mortality.
Does abnormal troponin I level on admission predict in-hospital mortality in hospitalized COVID-19 patients?
Cohort (n=649)
Does abnormal troponin I level on admission predict in-hospital mortality in hospitalized COVID-19 patients?
p-value: p=0.019
Elevated admission troponin I may predict higher in-hospital mortality in COVID-19; leaves open whether it should guide therapy or risk stratification.
OBJECTIVE: To describe the levels of troponin I in COVID-19 patients and its role in the prediction of their in-hospital mortality as a cardiac biomarker. METHODS: The current retrospective cohort study was performed on the clinical records of 649 COVID-19-related hospitalized cases with at leat one positive polymerase chain reaction (PCR) test in Tehran, Iran from February 2020 to early June 2020. The on admission troponin I level divided into two groups of ≤0.03ng/mL (normal) and >0.03ng/mL (abnormal). The adjusted COX-regression model was used to determine the relationship between the studied variables and patient's in-hospital mortality. RESULTS: =0.019). CONCLUSION: It seems that troponin I is one of the important factors related to in-hospital mortality of COVID-19 patients. Next, due to the high prevalence of cardiac complications in these patients, it is highly suggested to monitor and control cardiac biomarkers along with other clinical factors upon the patient's arrival at the hospital.
No takes yet. Share an insight, caveat, or question.
Aghajani et al. (2022) conducted a cohort in COVID-19 (n=649). Abnormal troponin I level (>0.03ng/mL) vs. Normal troponin I level (≤0.03ng/mL) was evaluated on In-hospital mortality (p=0.019). Abnormal admission troponin I levels (>0.03ng/mL) were significantly associated with in-hospital mortality among hospitalized COVID-19 patients (P=0.019).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: