Key result
Essential hypertension with cardiac, renal, and retinal complications is linked to reduced intrarenal blood flow.
Observational (n=22)
Redistribution of intrarenal blood flow occurs in patients with essential hypertension who have developed renal, cardiac, and retinal complications.
Reduced intrarenal flow associates with multi-organ complications in hypertension; hypothesis-generating and should not yet change practice.
Intrarenal blood flow was measured by the 133Xe washout method in 22 patients with essential hypertension. Mean RBF, the percentage of flow in component I, and fraction of renal mass supplied by component I were significantly reduced in patients with proteinuria, severe nephrosclerosis, cardiomegaly, and retinal changes of Keith-Wagener III and IV. Flow rate in component I was also reduced in the patients with severe nephrosclerosis, retinal changes of Keith-Wagener III and IV, and proteinuria. We conclude that redistribution of intrarenal blood flow occurs in essential hypertension with renal, cardiac, and retinal complications.
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Nomura et al. (2008) conducted an observational in Essential hypertension (n=22). Renal, cardiac, and retinal complications vs. Essential hypertension without these complications was evaluated on Intrarenal blood flow parameters (Mean RBF, percentage of flow in component I, fraction of renal mass supplied by component I). Intrarenal blood flow parameters were significantly reduced in essential hypertension patients with renal, cardiac, and retinal complications.
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