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March 1, 1996Kidney InternationalOpen Access

Computed tomography-derived intrarenal blood flow in renovascular and essential hypertension

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Why the study?

Does intrarenal perfusion measured by EBCT differ between patients with atherosclerotic renal artery stenosis, fibromuscular dysplasia, and essential hypertension?

Population

Hypertensive patients with well-preserved renal function, including those with atherosclerotic renal artery…

Comparison

Electron beam computed tomography to measure… vs Comparison among atherosclerotic renal artery…

Design

Cross-sectional

Authors

LLLilach O. LermanSTSandra J. TalerSTStephen C. Textor

Discussion

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Overview

May reflect multifactorial injury in atherosclerotic RAS; hypothesis-generating for perfusion imaging in renal artery disease.

Structured PICO

Does intrarenal perfusion measured by EBCT differ between patients with atherosclerotic renal artery stenosis, fibromuscular dysplasia, and essential hypertension?

P
Population
Hypertensive patients with well-preserved renal function, including those with atherosclerotic renal artery stenosis (N=20), fibromuscular dysplasia (N=10), and essential hypertension (N=28).
I
Intervention
Electron beam computed tomography (EBCT) to measure whole kidney, cortical, and medullary perfusion and volume
C
Comparator
Comparison among atherosclerotic renal artery stenosis, fibromuscular dysplasia, and essential hypertension groups
O
Outcome
Whole kidney, cortical, and medullary perfusion and volumesurrogate

In atherosclerotic renal artery stenosis, decreased cortical perfusion is not directly related to the degree of main renal artery stenosis, unlike in fibromuscular dysplasia, suggesting other pathophysiological factors contribute to renal failure.

Cite This Study

Lerman et al. (1996) studied this question.

synapsesocial.com/papers/6a7316fecdd331ef01acb5ddhttps://doi.org/10.1038/ki.1996.117
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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Unilateral Renal Hemodynamics and Characteristics of Dye-Dilution Curves in Patients with Essential Hypertension and Renal Disease1967 · 53 citations
  2. 2Are renal hemodynamics a key factor in the development and maintenance of arterial hypertension in humans?1994 · 102 citations
  3. 3Percutaneous transluminal renal angioplasty in management of atherosclerotic renovascular hypertension: results in 100 patients.1989 · 172 citations
  4. 4Responses of the stenosed and contralateral kidneys to [Sar1, Thr8] AII in human renovascular hypertension.1983 · 24 citations