Key result
Chronic stress and anxiety potentially drive mental illness through endocrine imbalance.
Why the study?
Diabetes and diabetic autonomic neuropathy significantly increase sudden cardiac death risk, driven by oxidative stress and autonomic dysfunction.
Does (r) Alpha Lipoic Acid reduce sudden cardiac death in geriatric patients with type 2 diabetes mellitus and autonomic neuropathy?
Population
133 patients (mean age 66y/o) with type II diabetes and DAN or CAN
Comparison
(r) Alpha Lipoic Acid vs untreated
Design
Observational cohort study
Follow-up
mean 6.31 yrs
Authors
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Antioxidant treatment in diabetic CAN may reduce SCD risk; leaves open need for RCTs before any practice change.
Case Report (n=3)
Does (r) Alpha Lipoic Acid reduce sudden cardiac death in geriatric patients with type 2 diabetes mellitus and autonomic neuropathy?
(r)-Alpha Lipoic Acid was associated with a significant reduction in sudden cardiac death and favorable autonomic tone changes in geriatric patients with type 2 diabetes and autonomic neuropathy.
Murray et al. (2020) conducted a case report in Anxiety and mental illnesses (n=3). Chronic stress was evaluated. Chronic stress and anxiety are hypothesized to cause an imbalance in the endocrine system, potentially leading to mental illnesses such as depression, schizophrenia, and Parkinson's disease.
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