Key result
R-alpha lipoic acid linked to ~43% lower SCD in geriatric T2D patients with dysautonomia.
Why the study?
Diabetes and autonomic neuropathy increase the risk of sudden cardiac death, and oxidative stress is a major cause of diabetic autonomic neuropathy.
Does (r) Alpha Lipoic Acid reduce Sudden Cardiac Death in geriatric type II diabetes mellitus patients with autonomic neuropathy?
Population
133 patients (mean age 66y/o) with type II diabetes and DAN or CAN
Comparison
(r) Alpha Lipoic Acid vs untreated
Design
Cohort study
Follow-up
Mean 6.31 yrs
Authors
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Antioxidant therapy may improve autonomic balance in DAN; hypothesis-generating for SCD reduction, needs prospective confirmation.
Cohort (n=133)
Open-label
No
Does (r) Alpha Lipoic Acid reduce Sudden Cardiac Death in geriatric type II diabetes mellitus patients with autonomic neuropathy?
Effect estimate: RRR 43%
Absolute Event Rate: 25% vs 44%
p-value: p=0.0076
(r)-Alpha Lipoic Acid supplementation is associated with a significant reduction in sudden cardiac death and improved autonomic function in older patients with type II diabetes and autonomic neuropathy.
Murray et al. (2020) conducted a cohort in Type 2 Diabetes Mellitus with dysautonomia (n=133). (r) Alpha Lipoic Acid vs. No (r) Alpha Lipoic Acid was evaluated on Sudden Cardiac Death (SCD) (RRR 43%, p=0.0076). (r)-Alpha Lipoic Acid reduced sudden cardiac death by 43% compared to no treatment in geriatric patients with type 2 diabetes and dysautonomia.
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