Key result
Landiolol linked to ~69% freedom from recurrent VT/VF in moderate to severe renal impairment.
Why the study?
The study investigated the effects of renal function on the efficacy and safety of landiolol in patients with hemodynamically unstable VT or VF refractory to Class III antiarrhythmic drugs.
Does landiolol improve efficacy and safety in patients with hemodynamically unstable ventricular tachycardia (VT) or ventricular fibrillation (VF) who were refractory to Class III antiarrhythmic drugs, regardless of renal function?
Observational (n=29)
Open-label
Yes
Does landiolol improve efficacy and safety in patients with hemodynamically unstable ventricular tachycardia (VT) or ventricular fibrillation (VF) who were refractory to Class III antiarrhythmic drugs, regardless of renal function?
Absolute Event Rate: 69.2% vs 81.8%
Renal function may not alter landiolol efficacy or safety in refractory VT/VF; hypothesis-generating post hoc data require prospective confirmation before practice change.
Background:Post hoc analysis was used to investigate the effects of renal function on the efficacy and safety of landiolol using data from the J-Land II study, which evaluated landiolol in patients with hemodynamically unstable ventricular tachycardia (VT) or ventricular fibrillation (VF) who were refractory to Class III antiarrhythmic drugs.
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Shiga et al. (2020) conducted an observational in Hemodynamically unstable ventricular tachycardia or ventricular fibrillation (n=29). Landiolol (eGFR <45 mL/min/1.73 m2) vs. Landiolol (eGFR ≥45 mL/min/1.73 m2) was evaluated on Proportion of patients free from recurrent hemodynamically unstable VT or VF during the 48-h efficacy assessment period. Landiolol prevented recurrent ventricular tachycardia or fibrillation in 69.2% of patients with moderate to severe renal impairment and 81.8% of patients with mild or no renal impairment.
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