Key result
Stimulating faster sympathetic afferent fibers lowers blood pressure while slower fibers raise it.
Population
Dogs and monkeys anesthetized with pentobarbital sodium
Design
Preclinical
Authors
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Animal data on fiber-specific reflexes warrant no clinical change; leaves open translation to human autonomic regulation or therapies.
Stimulation of sympathetic afferents elicits distinct depressor or pressor responses depending on the fiber type and anatomical location.
Kostreva et al. (1981) studied this question. Stimulation of sympathetic afferents was evaluated on Blood pressure response (depressor or pressor). Stimulation of sympathetic afferents with conduction velocities of 2.5-10 m/s caused a depressor response, whereas stimulation of fibers at 0.5-3.0 m/s elicited a pressor response.
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