What is the clinical evidence from this study?

Study design: Other. Population: Vagotomized intact-brain or spinal cats. Intervention: Electrical stimulation of afferent fibers in cardiac sympathetic nerves. Primary outcome: Pressor response (blood pressure rise).

What question did this study set out to answer?

To investigate the pressor reflexes induced by electrical stimulation of cardiac sympathetic afferent fibers.

June 1, 1971Circulation ResearchOpen Access

Pressor Reflexes Produced by Stimulation of Afferent Fibers in the Cardiac Sympathetic Nerves of the Cat

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Key result

Electrical stimulation of afferent fibers in cardiac sympathetic nerves of cats elicited a pressor response (maximum blood pressure rise of 21.5 mm Hg) that was abolished by phenoxybenzamine.

Population

vagotomized intact-brain or spinal cats

Design

Preclinical

Authors

DPD. F. PetersonArizona State University ABArthur BrownRutgers, The State University of New Jersey

Discussion

Member takes

Implication

Early cat data suggest sympathetic afferent pressor reflexes; leaves open human relevance and mechanisms.

Key Points

To investigate the pressor reflexes induced by electrical stimulation of cardiac sympathetic afferent fibers.
Electrical stimulation of cardiac sympathetic nerves in vagotomized intact-brain or spinal cats.
Administration of phenoxybenzamine hydrochloride to assess alpha-receptor involvement.
Sequential nerve sectioning to identify contributions of specific nerve branches to the pressor response.
Maximum blood pressure increase of 21.5 mm Hg during inferior cardiac nerve stimulation.
Maximum blood pressure increase of 14.1 mm Hg during pericoronary nerve stimulation.
C fiber excitation in the inferior cardiac nerve produced a stronger pressor response compared to Aδ fibers.

Structured PICO

Population

Vagotomized intact-brain or spinal cats undergoing electrical stimulation of cardiac sympathetic nerves.

Intervention

electrical stimulation of the central end of the cut left inferior cardiac or pericoronary nerve

Outcome

pressor response (blood pressure rise)surrogate

Stimulation of afferent fibers in cardiac sympathetic nerves in cats produces a pressor response primarily driven by C fibers.

Cite This Study

Peterson et al. (1971) studied Vagotomized intact-brain or spinal cats. Electrical stimulation of afferent fibers in cardiac sympathetic nerves was evaluated on Pressor response (blood pressure rise). Electrical stimulation of afferent fibers in cardiac sympathetic nerves of cats elicited a pressor response (maximum blood pressure rise of 21.5 mm Hg) that was abolished by phenoxybenzamine.

synapsesocial.com/papers/6a61cd1cf2fc5dc74fc1f5d8 https://doi.org/10.1161/01.res.28.6.605

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Pressor Reflexes Produced by Stimulation of Afferent Fibers in the Cardiac Sympathetic Nerves of the Cat

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Pressor Reflexes Produced by Stimulation of Afferent Fibers in the Cardiac Sympathetic Nerves of the Cat

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Also Consider