Key result
HTLV-I carrier children show ~88% initial anti-p40tax prevalence that can wane over time unlike mothers.
Observational (n=37)
Antibody levels to p40tax in HTLV-I carriers can decline over time, leading to loss of detectable antibodies in some children.
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Antibody loss in pediatric HTLV-I carriers may complicate serologic diagnosis; leaves open need for longitudinal monitoring studies.
Antibody to p40tax (anti-p40tax) in serum specimens obtained sequentially from a human T cell lymphotropic virus type I carrier population of mothers and children were assayed. The prevalences of anti-p40tax at the initial sampling were 88% (7/8) in children and 55% (16/29) in mothers. Two of the seven positive children lost their anti-p40tax during the investigation period, resulting in a final prevalence of 63% (5/8) in children. However, anti-p40tax status was constant in all the 22 mothers with multiple serum samples (15 remained positive and seven remained negative). A decline in the absorbance value of EIA for anti-p40tax was observed in seven of the 15 anti-p40tax positive mothers. This decline may result in the disappearance of anti-p40tax in some of them.
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Kusuhara et al. (1995) conducted an observational in HTLV-I carrier (n=37). HTLV-I carrier status was evaluated on Prevalence and sequential changes of anti-p40tax. In HTLV-I carriers, anti-p40tax prevalence was initially 88% in children and 55% in mothers; 2 of 7 positive children lost the antibody over time while maternal status remained constant.
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