Key result
Surgical resection of a 15-mm anterior mediastinal mass in an 85-year-old female led to a pathological diagnosis of leiomyosarcoma, with no recurrence or metastasis observed during follow-up.
Why the study?
Primary mediastinal sarcomas are extremely rare, and to date only few cases of anterior mediastinal leiomyosarcoma have been reported.
Case Report (n=1)
This case report describes a very rare occurrence of anterior mediastinal leiomyosarcoma in an 85-year-old female, contributing to the understanding of this rare disease.
Adds rare anterior mediastinal leiomyosarcoma case to sparse literature; hypothesis-generating and leaves optimal management open.
Primary mediastinal sarcomas are extremely rare. Additionally, mediastinal leiomyosarcomas account for approximately 9% of mediastinal sarcoma cases. Until date, only few cases of anterior mediastinal leiomyosarcomas have been reported. Herein, we report a case of an 85-year-old female with an anterior mediastinal mass of 15 mm. Histological examination revealed spindle tumor cells showing a fascicular growth pattern. Immunohistochemically, the tumor cells were focal positive for desmin, calponin, and α-smooth muscle actin. The pathological diagnosis was leiomyosarcoma. In conclusion, we encountered a case of a very rare leiomyosarcoma that occurred in the anterior mediastinum, and our report may contribute to the understanding of this disease.
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Ishikawa et al. (2021) conducted a case report in Anterior Mediastinal Leiomyosarcoma (n=1). Mediastinal tumor resection with the thymus was evaluated on Pathological diagnosis and clinical outcome. Surgical resection of a 15-mm anterior mediastinal mass in an 85-year-old female led to a pathological diagnosis of leiomyosarcoma, with no recurrence or metastasis observed during follow-up.
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