Key result
Elevated neutrophil counts are linked to greater thrombus burden and total coronary occlusion in AMI.
Why the study?
Does elevated leukocyte or neutrophil count correlate with coronary lesion severity in patients with acute myocardial infarction undergoing primary PCI?
Population
815 patients with acute myocardial infarction undergoing primary percutaneous coronary intervention from…
Design
Cohort
Follow-up
during hospitalization
Authors
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Caution against immediate clinical adoption in AMI; leaves open whether targeting neutrophils reduces occlusion risk.
Observational (n=815)
No
Does elevated leukocyte or neutrophil count correlate with coronary lesion severity in patients with acute myocardial infarction undergoing primary PCI?
p-value: p=.001
Elevated neutrophil count is an independent predictor of high thrombus burden and total coronary occlusion in patients with AMI undergoing primary PCI.
Liang et al. (2017) conducted an observational in Acute Myocardial Infarction (n=815). Neutrophil count ≥8.355 × 10^9/L vs. Lower neutrophil count was evaluated on High thrombus burden and total coronary occlusion (p=.001). Elevated neutrophil counts were significantly associated with thrombus burden (8.61 vs 7.48 × 10^9/L, P=0.001) and independently predicted total coronary occlusion in patients with AMI.
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