Key result
Leukocytosis and neutrophilia linked to higher risk of short-term CHF after acute STEMI.
Why the study?
Peripheral leukocyte count may have important prognostic implications in acute STEMI, but its association with short-term development of CHF after AMI is unclear.
Is high total leukocyte count associated with the short-term development of congestive heart failure after STEMI?
Population
200 patients with STEMI excluding chest pain >12 hours, trauma, infection, malignancy
Comparison
High total leukocyte count and neutrophilia vs normal leukocyte and neutrophil counts
Design
Cross-sectional study
Follow-up
In-hospital (short term)
Authors
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May support leukocyte monitoring for early HF risk post-STEMI; hypothesis-generating and should not yet change practice.
Cross-Sectional (n=200)
Is high total leukocyte count associated with the short-term development of congestive heart failure after STEMI?
p-value: p=< 0.016
High total leukocyte count and neutrophilia are associated with the short-term development of congestive heart failure and mortality after acute STEMI.
Jan et al. (2012) conducted a cross-sectional in Acute myocardial infarction ST-elevation (STEMI) (n=200). High total leukocyte count and neutrophilia vs. Normal total leukocyte count and neutrophil count was evaluated on Development of congestive heart failure (CHF) (p=< 0.016). High total leukocyte count (>11000 mm3) and neutrophilia were significantly associated with the short-term development of congestive heart failure after acute STEMI (p < 0.016 for neutrophilia).