Key result
The circumferential strain rate dispersion index was the single independent determinant of left ventricular end-systolic volume reduction after cardiac resynchronization therapy (β 0.69, p<0.0001).
Why the study?
Does the strain rate dispersion index predict changes in left ventricular volume and adverse cardiac events following cardiac resynchronization therapy better than time-delay indices?
Observational (n=40)
No
Does the strain rate dispersion index predict changes in left ventricular volume and adverse cardiac events following cardiac resynchronization therapy better than time-delay indices?
Effect estimate: β 0.69
p-value: p=<0.0001
The strain rate dispersion index (SRDI) is a useful echocardiographic predictor of left ventricular reverse remodeling and long-term cardiac events after cardiac resynchronization therapy.
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May aid CRT response prediction beyond time-delay indices; hypothesis-generating, requiring prospective validation before clinical adoption.
Iwano et al. (2013) conducted an observational in Heart Failure (n=40). Strain rate dispersion index (SRDI) vs. Time-delay indices was evaluated on Reduction in left ventricular end-systolic volume (ΔESV) at 6 months (β 0.69, p=<0.0001). The circumferential strain rate dispersion index was the single independent determinant of left ventricular end-systolic volume reduction after cardiac resynchronization therapy (β 0.69, p<0.0001).
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