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March 29, 2015International Cardiovascular Forum JournalOpen Access

Predictors of exercise capacity in heart failure

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Key result

TAPSE, E/e', and t-IVT independently predict poor 6-minute walk test performance in heart failure.

  • OR 0.076
  • 95% CI 0.017-0.335
  • P=0.001
  • n=111

Why the study?

Do echocardiographic parameters predict poor 6-minute walk test performance in patients with heart failure and reduced LVEF?

Population

111 patients with heart failure and reduced left ventricular ejection fraction, mean age 60±12 years, 56%…

Design

Cross-sectional

Authors

PIPranvera IbrahimiGeneral / Preventive / Lipids

Discussion

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Implication

Identified predictors may aid 6-MWT estimation in HFrEF; leaves open prospective validation before substituting for direct testing.

Study Design

Type

Cross-Sectional (n=111)

Structured PICO

Do echocardiographic parameters predict poor 6-minute walk test performance in patients with heart failure and reduced LVEF?

P
Population
111 patients (mean age 60 years, 44% female) with heart failure and reduced left ventricular ejection fraction who underwent same-day 6-minute walk test and echo-Doppler study.
E
Exposure
Echocardiographic assessment including TAPSE, E/e' ratio, and total isovolumic time (t-IVT)
O
Outcome
6-minute walk test (6-MWT) distance (dichotomized as ≤300m vs >300m)surrogate

Main Result

Odds Ratio: 0.076 (95% CI 0.017–0.335)

p-value: p=0.001

Echocardiographic markers of right ventricular dysfunction, elevated LV filling pressures, and dyssynchrony can independently predict poor exercise capacity in HFrEF patients.

Cite This Study

Pranvera Ibrahimi (2015) conducted a cross-sectional in Heart failure with reduced left ventricular ejection fraction (n=111). Echocardiographic parameters (TAPSE, E/e', t-IVT) was evaluated on Poor 6-minute walk test performance (≤300m) (OR 0.076, 95% CI 0.017-0.335, p=0.001). In patients with heart failure, TAPSE (OR 0.076; 95% CI 0.017-0.335; p=0.001), E/e', and t-IVT independently predicted poor 6-minute walk test performance (≤300m).

synapsesocial.com/papers/6aa14f40b8a7879f1e7c5841https://doi.org/10.17987/icfj.v1i1.14
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Value of Left Atrial Function in Predicting Exercise Capacity in Heart Failure With Moderate to Severe Left Ventricular Systolic Dysfunction2005 · 39 citations
  2. 2Right heart dysfunction assessed with echography, B-type natriuretic peptide and cardiopulmonary test in patients with chronic heart failure2008 · 21 citations
  3. 3Normal long axis function1999 · 218 citations
  4. 4Quality and Outcomes of Heart Failure Care in Older Adults: Role of Multidisciplinary Disease‐Management Programs2002 · 57 citations
  5. 5Mortality and Morbidity Remain High Despite Captopril and/or Valsartan Therapy in Elderly Patients With Left Ventricular Systolic Dysfunction, Heart Failure, or Both After Acute Myocardial Infarction2005 · 102 citations