Key result
Lower pulse pressure, proportionate pulse pressure, and ejection fraction independently predicted limited functional capacity (6-MWD < 300 m) in patients with HFmEF and HFpEF.
Why the study?
Patients with HF develop progressive limitation of functional capacity, which is reflected by the 6-min walk test.
Cross-Sectional (n=90)
Simple bedside measurement of blood pressure parameters, such as pulse pressure and proportionate pulse pressure, correlates with functional capacity and can predict limited 6-minute walk distance in patients with HFmEF and HFpEF.
Simple BP parameters may aid bedside functional assessment in HFmEF/HFpEF; leaves open prospective validation and outcome impact.
ObjectiveTo assess different blood pressure (BP) parameters and their changes after 6-min walk test (6-MWT) in patients with heart failure with midrange ejection fraction (HFmEF) and heart failure with preserved ejection fraction (HFpEF) and correlate them with the functional capacity (FC) as assessed by 6-min walk distance (6-MWD).BackgroundThe 6-MWT reflects the daily activity of patients with HF who develop progressive limitation of FC.Patients and methodsA total of 40 patients with HFmEF and 50 patients with HFpEF were enrolled. The 6-MWT was performed according to the American Thoracic Society guidelines 2002. Different BP parameters were measured before and after 6-MWT, and 6-MWD was recorded.ResultThe mean 6-MWD was 325.3 ± 56.84 m in all patients, 316.1 ± 61.33 m in HFmEF group, 332.66 ± 52.44 m HFpEF group. The 6-MWD and limited FC showed no significant difference between the two groups. Independent predictors of limited FC assessed by the 6-MWD were lower EF, pulse pressure (PP), and proportionate pulse pressure (PPP) and higher diastolic blood pressure in patients with HFmEF and lower EF in patients with HFpEF. Cutoff points for prediction of limited FC as assessed by 6-MWD less than 300 m included PP less than 32.5 mmHg and PPP less than 30.22% in patients with HFmEF, PP less than 37.5 mmHg and PPP less than 32.67% in patients with HFpEF, and EF less than 42.5% in all patients.ConclutionA simple bedside measurement of BP parameters correlates with the FC and can predict limited FC represented by 6-MWD less than 300 m in patients with HFmEF and HFpEF.
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Algamal et al. (2022) conducted a cross-sectional in Heart failure with preserved and midrange ejection fraction (n=90). Blood pressure parameters was evaluated on Functional capacity assessed by 6-min walk distance (6-MWD). Lower pulse pressure, proportionate pulse pressure, and ejection fraction independently predicted limited functional capacity (6-MWD < 300 m) in patients with HFmEF and HFpEF.
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