Key result
Reserpine-induced ganglionic norepinephrine depletion markedly enhances sympathetic nerve transmission in cats and rabbits.
Why the study?
Does ganglionic norepinephrine modulate sympathetic synaptic transmission in cats and rabbits?
Population
Cats and rabbits (superior cervical sympathetic ganglia)
Design
Preclinical
Authors
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Norepinephrine may modulate ganglionic transmission in animal models; leaves open its relevance to human autonomic regulation.
Does ganglionic norepinephrine modulate sympathetic synaptic transmission in cats and rabbits?
The study demonstrates that norepinephrine in ganglia modulates the action of acetylcholine, supporting its role in sympathetic synaptic transmission.
Costa et al. (1961) studied this question. Reserpine was evaluated on Transmission of nerve impulses in superior cervical sympathetic ganglia. Reserpine-induced depletion of ganglionic norepinephrine markedly enhanced transmission of nerve impulses in superior cervical sympathetic ganglia of cats and rabbits.
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