Key result
Cibenzoline fails to prevent recurrent LVPG in HOCM complicated by concurrent Takotsubo cardiomyopathy.
Case Report (n=1)
No
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Takotsubo cardiomyopathy can cause the reappearance of the left ventricular outflow tract gradient in patients with HOCM, overcoming the previous therapeutic effect of cibenzoline.
An 84-year-old woman diagnosed with hypertrophic obstructive cardiomyopathy (HOCM) was referred to our hospital due to chest pain associated with an increased level of troponin T. Following the administration of cibenzoline, the left ventricular outflow pressure gradient (LVPG) completely disappeared. Left ventricular pressure pullback tracing subsequently demonstrated the "reappearance" of the LVPG. Left ventriculography showed apical ballooning with excessive contractions at the base of heart, and we therefore made a diagnosis of Takotsubo cardiomyopathy in a patient with HOCM. Hypercontractions of the base of the heart associated with Takotsubo cardiomyopathy may be responsible for the "reappearance" of LVPG in this case.
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Ochiumi et al. (2015) conducted a case report in Hypertrophic obstructive cardiomyopathy and Takotsubo cardiomyopathy (n=1). Cibenzoline was evaluated on Left ventricular outflow pressure gradient (LVPG). In an 84-year-old woman with hypertrophic obstructive cardiomyopathy, treatment with cibenzoline did not prevent the reappearance of a left ventricular pressure gradient of 100 mmHg due to concurrent Takotsubo cardiomyopathy.
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