Key result
CHD linked to ~51% lower insulin-stimulated glucose uptake in adipocytes, particularly in Asian subjects.
Why the study?
Does adipocyte insulin sensitivity and in vivo insulin resistance differ between subjects with and without coronary heart disease?
Case-Control (n=90)
Does adipocyte insulin sensitivity and in vivo insulin resistance differ between subjects with and without coronary heart disease?
Absolute Event Rate: 56% vs 115%
p-value: p=< 0.05
Abnormalities in adipocyte function and insulin sensitivity are present in patients with coronary heart disease, particularly in Asian subjects, and may contribute to its etiology.
No takes yet. Share an insight, caveat, or question.
Adipocyte insulin resistance may contribute to CHD etiology, especially in Asians; hypothesis-generating and should not yet change practice.
Frost et al. (1998) conducted a case-control in Coronary heart disease (n=90). Coronary heart disease vs. Caucasian subjects without coronary heart disease was evaluated on Insulin-stimulated glucose uptake in adipocytes (attomol min(-1).mm2) (p=< 0.05). Coronary heart disease was associated with lower insulin-stimulated glucose uptake in adipocytes compared to controls (56 vs 115 attomol min(-1).mm2, p<0.05), particularly in Asian subjects.
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