Key result
Alcohols, bleach, and povidone iodine inactivate murine norovirus, achieving a ~4-log10 reduction in viral titer.
Why the study?
Are hospital disinfectants effective against murine norovirus as a surrogate for human norovirus?
Are hospital disinfectants effective against murine norovirus as a surrogate for human norovirus?
Murine norovirus is sensitive to common hospital disinfectants, and viral RNA detection by RT-PCR does not reliably indicate the presence of infectious virus.
May guide disinfectant choice against norovirus surrogates; leaves open translation to human norovirus in hospitals.
Murine norovirus (MNV) was used as a surrogate to study resistance of human norovirus to disinfectants used in hospitals. MNV was sensitive to alcohol, alcohol hand rubs, bleach, and povidone iodine-based disinfectant. Real-time reverse transcription-PCR results indicated that the presence of viral RNA did not correlate with the presence of infectious virus.
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Belliot et al. (2008) studied Norovirus surrogate resistance. Disinfectants (alcohols, bleach, povidone iodine, hand rubs) vs. Untreated control was evaluated on Reduction in viral titer (log10 PFU/ml). Murine norovirus, used as a surrogate for human norovirus, was effectively inactivated by alcohols, bleach, and povidone iodine-based disinfectants, achieving at least a 4-log10 reduction in viral titer.
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