June 27, 2007Diabetes
Effects of the Renin-Angiotensin System Genes and Salt Sensitivity Genes on Blood Pressure and Atherosclerosis in the Total Population and Patients With Type 2 Diabetes
Key result
Three RAS risk genotypes are linked to ~7 mmHg higher SBP in T2D.
- MD 6.9 mmHg
- P=0.04
Why the study?
Does the accumulation of risk genotypes for RAS and salt sensitivity genes increase blood pressure and atherosclerosis in the total population and patients with type 2 diabetes?
Population
Total population and patients with type 2 diabetes
Comparison
Presence of multiple risk genotypes for three… vs Absence of risk genotypes or presence of fewer…
Design
Cohort
Authors
Discussion
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Implication
RAS genotypes linked to higher SBP in type 2 diabetes; hypothesis-generating and should not yet change practice.
Study Design
Type
Cohort
Structured PICO
Does the accumulation of risk genotypes for RAS and salt sensitivity genes increase blood pressure and atherosclerosis in the total population and patients with type 2 diabetes?
P
Population
Participants from the population-based Rotterdam Study cohort, analyzed for the combined effects of RAS and salt sensitivity genes on blood pressure and atherosclerosis.
E
Exposure
Presence of multiple risk genotypes for three renin-angiotensin system (RAS) genes and three salt sensitivity genes
C
Comparator
Absence of risk genotypes or presence of fewer risk genotypes
O
Outcome
Systolic blood pressure, pulse pressure, and mean intima-media thicknesssurrogate
Main Result
Mean Difference: 6.9
p-value: p=0.04
The accumulation of risk genotypes for renin-angiotensin system and salt sensitivity genes is associated with increased blood pressure and atherosclerosis in patients with type 2 diabetes.
Cite This Study
Yazdanpanah et al. (2007) conducted a cohort in Type 2 diabetes and general population. Risk genotypes of the renin-angiotensin system (RAS) and salt sensitivity genes vs. No risk genotypes or fewer risk genotypes was evaluated on Systolic blood pressure (MD 6.9 mmHg, p=0.04). Among type 2 diabetic patients, carrying three risk genotypes for the RAS genes was associated with a 6.9 mmHg higher systolic blood pressure compared to carrying no risk genotypes (P for trend=0.04).