Key result
ABCA1 gene polymorphisms rs2472510 and rs2515614 are linked to hypertension in Chinese Han adults.
Why the study?
Hypertension is rising as a major global public health burden, prompting investigation into the association between ABCA1 gene polymorphisms and hypertension among Chinese Han adults.
Are ABCA1 gene polymorphisms associated with the risk of hypertension in Chinese Han adults?
Observational (n=2,296)
Are ABCA1 gene polymorphisms associated with the risk of hypertension in Chinese Han adults?
Polymorphisms in the ABCA1 gene (rs2472510 and rs2515614) and specific haplotypes are associated with an increased risk of hypertension in the Chinese Han population.
Should not change practice; leaves open ABCA1 variants as hypertension risk factors in Chinese Han adults pending prospective validation.
Background: Hypertension is rising as a major public health burden around the world. This study explored the association between single-nucleotide polymorphisms (SNPs) in the adenosine triphosphate (ATP)-Binding Cassette Subfamily A1 (ABCA1) gene and hypertension among Chinese Han adults. Method: A total of 2,296 Han Chinese in southeast China were recruited for this study. We collected medical reports, lifestyle details, and blood samples from individuals. The polymerase chain reaction-ligase detection reaction (PCR-LDR) method was used to detect the genotypes of these SNPs in the ABCA1 gene. Results: After adjusting some covariates, the additive and recessive models of the rs2472510 and rs2515614 were significantly associated with hypertension. The haplotypes TCTA (rs2297406-rs2472433-rs2472510-rs2515614) were associated with high SBP, and the haplotypes CCTA, TCTA, and TTTA were associated with high diastolic blood pressure (DBP). Conclusion: The results of the relationship between the polymorphisms of rs2297406, rs2472433, rs2472510, and rs2515614 in ABCA1 and hypertension in southeastern China would provide a theoretical basis for genetic screening and disease prevention.
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Ren et al. (2022) conducted an observational in Hypertension (n=2,296). ABCA1 gene polymorphisms was evaluated on Hypertension. Additive and recessive models of ABCA1 gene polymorphisms rs2472510 and rs2515614 were significantly associated with hypertension in Chinese Han adults.
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