March 1, 1997Hypertension
Contrasting Autonomic and Hemodynamic Effects of Insulin in Healthy Elderly Versus Young Subjects
Key result
Acute hyperinsulinemia linked to a ~27% increase in forearm vascular resistance in healthy elderly subjects.
- P<.05
- n=22
Why the study?
Does aging alter the sympathetic and vascular responses to acute physiological increases in plasma insulin levels?
Population
22 healthy, normotensive subjects comprising 10 elderly and 12 young matched for body mass index.
Comparison
90-minute hyperinsulinemic/euglycemic clamp to… vs Comparison between elderly and young subjects
Design
Cross-sectional
Follow-up
90 minutes
Authors
Discussion
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Implication
May heighten hypertension risk via insulin in elderly; leaves open causality and need for prospective studies.
Study Design
Type
Observational (n=22)
Structured PICO
Does aging alter the sympathetic and vascular responses to acute physiological increases in plasma insulin levels?
P
Population
22 healthy, normotensive subjects (10 elderly, 12 young) matched for body mass index, evaluated during a 90-minute hyperinsulinemic/euglycemic clamp.
I
Intervention
90-minute hyperinsulinemic/euglycemic clamp to acutely increase plasma insulin levels
C
Comparator
Comparison between elderly and young subjects
O
Outcome
Sympathetic and vascular responses (muscle sympathetic nerve activity, forearm blood flow, heart rate, blood pressure, forearm vascular resistance, and insulin sensitivity)surrogate
Main Result
p-value: p=<.05
Acute hyperinsulinemia causes vasodilation in healthy young adults but paradoxical vasoconstriction in healthy elderly individuals, which may potentiate insulin resistance.
Cite This Study
Hausberg et al. (1997) conducted an observational in Healthy, normotensive (n=22). Hyperinsulinemic/euglycemic clamp vs. Young subjects (comparing elderly vs young) was evaluated on Forearm vascular resistance (p=<.05). Acute hyperinsulinemia caused vasoconstriction in healthy elderly subjects (forearm vascular resistance increased from 37 to 47 units), as opposed to vasodilation in young adults (P<.05).