Key result
Aging and essential hypertension are linked to lower insulin sensitivity and reduced sodium excretion during hyperinsulinemia.
Why the study?
The influence of aging on insulin sensitivity in glucose metabolism and renal sodium handling under hyperinsulinemia, which may relate to high blood pressure in insulin-resistant subjects, was unclear.
Does aging and essential hypertension affect insulin sensitivity and renal sodium handling under hyperinsulinemia?
Observational (n=113)
Does aging and essential hypertension affect insulin sensitivity and renal sodium handling under hyperinsulinemia?
Impairments in insulin sensitivity and insulin-induced renal vasodilation with aging may contribute to age-related blood pressure elevation through renal sodium retention, abnormalities that appear earlier in essential hypertensives.
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May link insulin resistance to sodium retention in aging hypertension; hypothesis-generating and requires prospective confirmation before clinical implications.
Miyazaki et al. (1998) conducted an observational in Essential hypertension (n=113). Aging and hypertension vs. Young normotensives was evaluated on Insulin sensitivity (M value) and urinary sodium excretion (UNaV). Aging and essential hypertension were associated with significantly lower insulin sensitivity and decreased urinary sodium excretion under hyperinsulinemia compared to young normotensives.
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