October 29, 2004AJP Heart and Circulatory Physiology

Meal-related increases in vascular reactivity are impaired in older and diabetic adults: insights into roles of aging and insulin in vascular flow

View Full Paper

Ask AI

Bookmark

Why the study?

Does a high-fat meal induce different vascular reactivity responses in older and diabetic adults compared to young healthy adults?

Population

45 subjects: 15 Type 2 diabetic subjects, 15 age-, gender-, and BMI-matched older control subjects, and 15…

Comparison

Standardized high-fat meal (1,030 kcal, 61 g fat) vs Premeal values and comparison across the three…

Design

Cross-sectional

Follow-up

6 hours

Authors

MSMichael R. SkiltonGeneral / Preventive / Lipids KGKaye A. GriffithsAnzac Research Institute LMLynda MolyneauxThe University of Sydney

Discussion

Member takes

Implication

Age drives postprandial vascular impairment independent of diabetes; hypothesis-generating and should not yet change clinical practice.

Structured PICO

Does a high-fat meal induce different vascular reactivity responses in older and diabetic adults compared to young healthy adults?

Population

45 subjects: 15 Type 2 diabetic subjects (age 58 +/- 8 yr), 15 age-, gender-, and BMI-matched older control subjects (age 57 +/- 9 yr), and 15 healthy young control subjects (age 33 +/- 7 yr).

Intervention

Standardized high-fat meal (1,030 kcal, 61 g fat)

Comparator

Premeal values and comparison across the three groups (diabetic, older controls, young controls)

Outcome

Postprandial vascular responses (resting blood flow and hyperemic area under curve flow) measured by strain gauge plethysmography and ultrasound at 3 and 6 hours post-mealsurrogate

Impaired postprandial vasodilator responses in older adults are primarily driven by aging rather than insulin resistance or diabetes.

Cite This Study

Skilton et al. (2004) studied this question.

synapsesocial.com/papers/6a805223e1341be402e46e85 https://doi.org/10.1152/ajpheart.00484.2004

View Full Paper

Ask AI

Bookmark

Meal-related increases in vascular reactivity are impaired in older and diabetic adults: insights into roles of aging and insulin in vascular flow

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Meal-related increases in vascular reactivity are impaired in older and diabetic adults: insights into roles of aging and insulin in vascular flow

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider