Impairment of Peripheral Blood Flow Responses in Diabetes Resembles an Enhanced Aging Effect

60 subjects: 40 people with diabetes and 20 age- and sex-matched healthy control subjects.

Exposure to diabetes; physiological testing including three 1-minute stressor tasks (mental arithmetic, contralateral hand grip, and immersion of the contralateral hand in ice water) to induce vasoconstriction, and a local heat stimulus of 45 degrees C for 5 minutes to induce vasodilatation.

Age- and sex-matched healthy control subjects undergoing the same physiological testing.

Cutaneous blood flow responses (vasoconstriction and vasodilatation) measured using laser Doppler techniques.surrogate