Key result
ACE G2350A polymorphism A allele linked to essential hypertension and T2DM in Malaysian patients.
Why the study?
Is the ACE G2350A polymorphism associated with essential hypertension and type 2 diabetes mellitus in Malaysian subjects?
Case-Control (n=265)
Is the ACE G2350A polymorphism associated with essential hypertension and type 2 diabetes mellitus in Malaysian subjects?
p-value: p=<0.05
The A allele of the ACE G2350A polymorphism is significantly associated with essential hypertension and type 2 diabetes mellitus in the Malaysian population.
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Association of ACE G2350A A allele with hypertension and diabetes in Malaysians is hypothesis-generating; requires prospective validation before clinical consideration.
Ismail et al. (2008) conducted a case-control in Essential Hypertension and Type 2 Diabetes Mellitus (n=265). Angiotensin-Converting Enzyme (ACE) G2350A polymorphism vs. Control subjects was evaluated on Frequency of the A allele of the ACE G2350A polymorphism (p=<0.05). The A allele of the ACE G2350A polymorphism was significantly more frequent in Malaysian subjects with essential hypertension, type 2 diabetes, or both compared to controls (20.71%; P<0.05).
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