Key result
Olanzapine induces Q-Tc changes in ~38% of patients, driving both shortening and prolongation unlike risperidone.
Why the study?
Does olanzapine induce different Q-Tc interval changes compared to risperidone in female inpatients with schizophrenia?
Population
268 female inpatients with schizophrenia
Comparison
Olanzapine vs Risperidone
Design
RCT, random assignment to olanzapine or risperidone, open study
Follow-up
until discharge
Authors
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Olanzapine warrants QTc shortening vigilance in female schizophrenia inpatients unlike risperidone; extends knowledge of antipsychotic-specific repolarization effects.
RCT (n=268)
Open-label
random assignment
Does olanzapine induce different Q-Tc interval changes compared to risperidone in female inpatients with schizophrenia?
Absolute Event Rate: 37.83% vs 30%
In female inpatients with schizophrenia, olanzapine is uniquely associated with Q-Tc shortening, whereas risperidone is associated with expected Q-Tc prolongation.
Shafti et al. (2014) conducted an RCT in schizophrenia (n=268). Olanzapine vs. Risperidone was evaluated on Q-Tc changes. Olanzapine induced Q-Tc changes in 37.83% of patients (24.32% shortening, 13.51% prolongation), whereas risperidone induced Q-Tc changes in 30% (restricted to prolongation only).
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