Why the study?
Prolongation of the Q-Tc interval is a surrogate marker for drug-induced torsade de pointes, prompting comparison of the electrocardiographic safety of olanzapine versus risperidone in schizophrenic patients.
Does olanzapine alter electrocardiographic patterns, specifically the Q-Tc interval, compared to risperidone in female inpatients with schizophrenia?
RCT (n=268)
Open-label
Random assignment
No
Does olanzapine alter electrocardiographic patterns, specifically the Q-Tc interval, compared to risperidone in female inpatients with schizophrenia?
Absolute Event Rate: 37.83% vs 30%
p-value: p=0.17
Both olanzapine and risperidone can induce Q-Tc changes in healthy schizophrenic patients, but olanzapine uniquely demonstrates a propensity to cause Q-Tc shortening.
Introduction: Prolongation of the Q-Tc interval is commonly accepted as a surrogate marker for the ability of a drug to cause torsade de pointes (TdP). In the present study, safety of olanzapine vs. risperidone was compared among a cluster of schizophrenic patients, to see the frequency of the electrocardiographic alterations that can be induced by those atypical antipsychotics.
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Saeed Shoja Shafti (2019) conducted an RCT in Schizophrenia (n=268). Olanzapine vs. Risperidone (4-8 mg/day) was evaluated on Total Q-Tc interval changes (prolongation or shortening) (95% CI -0.03, 0.19, p=0.17).
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