Key result
Lymphocytic choriomeningitis virus induces coronary allograft vasculopathy in murine transplants via natural killer cells.
Why the study?
Does viral infection induce coronary allograft vasculopathy in a T- and B-lymphocyte deficient murine model?
Population
Heterotopic murine cardiac transplants in a parental to F1 combination in animals lacking both T- and…
Comparison
Recipient infection with lymphocytic… vs Uninfected controls
Design
Preclinical
Authors
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Viral infection may induce coronary allograft vasculopathy via NK cells independently of adaptive immunity; leaves open relevance to human cardiac transplant outcomes.
Does viral infection induce coronary allograft vasculopathy in a T- and B-lymphocyte deficient murine model?
Viral infection can induce coronary allograft vasculopathy via a natural killer cell-dependent pathway even in the absence of T- and B-lymphocytes.
Graham et al. (2009) studied Cardiac allograft vasculopathy. Lymphocytic choriomeningitis virus infection vs. Uninfected controls was evaluated on Development of coronary vasculopathy. Lymphocytic choriomeningitis virus infection induced de novo coronary allograft vasculopathy in murine cardiac transplants lacking T- and B-lymphocytes via a natural killer cell-dependent pathway.
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