July 1, 1995Journal of the American Geriatrics Society
Utility of Beta‐Blockade Treatment for Older Postinfarction Patients
Key result
Metoprolol after MI in older adults is linked to ~76% lower mortality.
- RR 0.24
- 95% CI 0.11-0.54
- P<.001
- n=118
Authors
Discussion
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Implication
Should not yet change post-MI beta-blocker practice in older adults; leaves open need for randomized confirmation of mortality benefit.
Study Design
Type
Cohort (n=118)
Multicenter
No
PICO
P
Population
118 older adults (aged 60-89) post-myocardial infarction who were suitable for beta-blocker therapy.
E
Exposure / Comparator
Metoprolol vs No beta-blocker therapy (≥ 25 mg/day for at least 5 days)
O
Primary Outcome
Mortality — RR 0.24 (0.11-0.54), p=<.001
Main Result
Relative Risk: 0.24 (95% CI 0.11–0.54)
p-value: p=<.001
Limitations
- Methodologic limitations may explain the lack of reduction in reinfarctions or rehospitalizations.
Cite This Study
Park et al. (1995) conducted a cohort in Myocardial infarction (n=118). Metoprolol vs. No beta-blocker therapy was evaluated on Mortality (RR 0.24, 95% CI 0.11-0.54, p=<.001). Metoprolol therapy after myocardial infarction in older adults significantly reduced age-adjusted mortality (RR 0.24; 95% CI 0.11-0.54; P<.001).