Key result
Telmisartan added to calcium channel blockers significantly reduced office and home blood pressure, urinary albumin excretion, baPWV, and left ventricular mass in low-risk hypertensive patients.
Why the study?
Does telmisartan improve renal function, vascular function, and left ventricular mass in low-risk hypertensive patients not meeting BP goals with CCBs?
Does telmisartan improve renal function, vascular function, and left ventricular mass in low-risk hypertensive patients not meeting BP goals with CCBs?
Adding telmisartan to CCB therapy in low-risk hypertensive patients improves blood pressure, renal function, vascular stiffness, and left ventricular mass, with effects correlating with salt intake.
May support telmisartan add-on to CCBs for BP and organ damage reduction in low-risk hypertension; leaves open prospective validation before practice change.
We examined calcium channel blockers (CCBs) and angiotensin receptor II blockers in low-risk hypertensives to evaluate renal, vascular function and left ventricular mass (LVM) from the viewpoint of salt intake (SI). Low-risk hypertensives who had not met blood pressure (BP) goals with CCB were administered telmisaltan. Office and home BP, urinary albumin excretion (uAE), brachial ankle pulse wave velocity (baPWV) and LVM were significantly reduced. uAE and baPWV correlated with SI. It is therefore necessary to evaluate the organ-protecting effects from the viewpoint of SI. In low-risk hypertensives, telmisartan with CCB improves renal, vascular function and LVM.
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Watanabe et al. (2012) studied Low-risk essential hypertension. Telmisartan was evaluated on Office and home blood pressure, urinary albumin excretion, brachial ankle pulse wave velocity, and left ventricular mass. Telmisartan added to calcium channel blockers significantly reduced office and home blood pressure, urinary albumin excretion, baPWV, and left ventricular mass in low-risk hypertensive patients.
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