Key result
FMD vaccination at 8 weeks in Hanwoo calves led to decreased FMD percentage inhibition at 16 weeks in 65.9% of calves, with higher pre-vaccination PI in those with decreased post-vaccination PI.
Why the study?
Few studies have confirmed the optimal timing of foot-and-mouth disease vaccination in newborn calves.
Does FMD vaccination at 8 and 12 weeks of age induce an effective antibody response in Hanwoo beef calves with maternal-derived antibodies?
Cohort (n=82)
Does FMD vaccination at 8 and 12 weeks of age induce an effective antibody response in Hanwoo beef calves with maternal-derived antibodies?
FMD vaccination at 8 weeks of age in Hanwoo calves may be too early due to interference from high levels of maternal-derived antibodies.
High maternal antibodies may blunt FMD response to vaccination at 8 weeks in Hanwoo calves; supports individualized timing assessment but leaves optimal schedule open for prospective trials.
Foot-and-mouth disease (FMD) vaccinations have been conducted in Korea for > 10 years. However, few studies have confirmed the optimal timing of FMD vaccination in newborn calves. In this study, we aimed to evaluate changes in antibodies before and after FMD vaccination and identify potential factors affecting FMD maternal-derived antibodies in newborn calves. Calves were vaccinated at 8 and 12 weeks of age. Blood samples were obtained from dams 6 weeks before the estimated due date and from calves at 8 (pre-vaccination), 12, and 16 weeks of age. Antibodies against the FMD virus (FMDV) structural proteins were detected using Priocheck FMDV type O antibody enzyme-linked immunosorbent assay. Among 82 calves, 54 (65.9 %) exhibited a decrease in FMD percentage inhibition (PI) at 16 weeks. The mean pre-vaccination FMD PI values of calves whose FMD PI decreased and increased after vaccination were 92.4 ± 9.4 and 72.4 ± 16.9, respectively (p < 0.05). Our results indicate that FMD vaccination at 8 weeks is early due to the high levels of maternal-derived FMD antibodies in the body of Hanwoo calves. The FMD PI of the dam (β = 0.636) exhibited the most significant impact on the FMD PI of 8-week-old calves, followed by calf birth weight (β = 0.200) (p < 0.05). Calves born to dams with high FMD PI and heavy birth weight exhibited high FMD PI at 8 weeks.
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Kim et al. (2025) conducted a cohort in Foot-and-mouth disease (FMD) maternal antibodies (n=82). FMD vaccination at 8 and 12 weeks was evaluated on Decrease in FMD percentage inhibition (PI) at 16 weeks. FMD vaccination at 8 weeks in Hanwoo calves led to decreased FMD percentage inhibition at 16 weeks in 65.9% of calves, with higher pre-vaccination PI in those with decreased post-vaccination PI.
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