Key result
Split-dose FMD vaccination boosts SN antibody titers and protects calves against virulent challenge.
Why the study?
The immune response of newborn calves to FMD vaccination, particularly those born to vaccinated versus unvaccinated cows, was studied to evaluate vaccination timing and dosing.
Does vaccination with split doses of FMD vaccine induce a protective immune response in newborn calves?
Does vaccination with split doses of FMD vaccine induce a protective immune response in newborn calves?
Vaccination of newborn calves with FMD vaccine in split doses at a 21-day interval successfully induces protective immunity, even within a week after birth.
May inform early FMD vaccination in calves; leaves open field efficacy, duration, and cross-serotype protection.
Summary : The immune response of calves (1-90 days old) born to FMD vaccinated and unvaccinated cows, after vaccination with mono valent saponified gel type A FMD vaccine, was studied. Most of the prevaccination sera of calves (born to FMD vaccinated cows) showed varying levels of maternal antibody with the SN indices ranging from 0.5 to 3.2, while those born to unvaccinated cows showed negligible levels. Calves of both groups showed significant rise in SN antibody titres at 21 days post-vaccination. However, this rise was more appre ciable in calves (born to vaccinated cows) having log SN index less than 1.0 before vaccination and in those which were born to unvaccinated cows. The second inoculation of other half of the adult dose at 21 days after primary vaccination resulted in boosting up the antibody response in all calves. The calves vaccinated twice withstood challenge infection with homologous virulent virus. These findings indicate that vaccina tion of calves with FMD vaccine given in split doses at 21 days interval may be taken up successfully even within a week after birth.
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Shankar et al. (1982) studied Foot and mouth disease (FMD). Monovalent saponified gel type A FMD vaccine vs. Calves born to unvaccinated cows was evaluated on SN antibody titres. Vaccination of calves with monovalent saponified gel type A FMD vaccine in split doses at a 21-day interval produced a significant rise in SN antibody titres and protected against virulent challenge.
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