Key result
Maternal colostrum cells fail to modify FMD vaccine responses, while maternal antibodies interfere with humoral immunity.
Why the study?
The influence of maternal antibodies and immune cells transferred through colostrum on calves' immune responses to foot-and-mouth disease vaccines is not well understood.
Do maternal immune cells transferred by colostrum influence the immune responses to foot-and-mouth disease primary vaccination in calves?
Do maternal immune cells transferred by colostrum influence the immune responses to foot-and-mouth disease primary vaccination in calves?
Maternal immune cells in colostrum do not affect calf immune responses to FMD vaccination, though maternal antibodies interfere with humoral immunity.
Maternal antibodies may blunt FMD vaccine responses in calves; leaves open whether colostral cells influence other antigens or species.
Little is known about the influence of maternal antibodies and immune cells transferred through colostrum on the immune responses of calves to the currently used foot-and-mouth disease (FMD) vaccines. Here we evaluated the humoral and cellular immune responses induced by vaccination of colostrum-deprived calves and calves that received equivalent amounts of colostrum preparations that differed in the presence or absence of maternal immune cells but contained the same quantity and quality of anti-foot-and-mouth disease virus (FMDV) antibodies. Three groups of 32-d-old calves (n = 3 per group) were deprived of colostrum and fed either whole immune colostrum or a cell-free colostrum preparation containing only anti-FMDV antibodies. All groups were immunized with 1 dose of an oil-adjuvanted commercial vaccine. Blood samples were collected periodically before vaccination and weekly after vaccination. Immune responses specific to FMDV were assessed based on T-cell proliferation, IFN-γ production, total and neutralizing serum antibodies, and isotype profile. All vaccinated calves developed IFN-γ and lymphoproliferative responses, irrespective of the colostrum received. Colostrum-deprived animals responded to vaccination with a primary IgM response followed by an increase of IgG 1 titers. Conversely, antibody titers decreased in all colostrum-fed calves after vaccination. This study demonstrates for the first time that maternal immune cells transferred to the calves through colostrum do not modify immune responses to FMD vaccine, and it confirms the interference of maternal antibodies in the induction of humoral but not cell-mediated immune responses.
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Bucafusco et al. (2019) studied Foot-and-mouth disease (n=9). Whole immune colostrum vs. Cell-free colostrum and colostrum-deprived calves was evaluated on Immune responses specific to FMDV (T-cell proliferation, IFN-γ production, total and neutralizing serum antibodies). Maternal immune cells transferred through colostrum did not modify immune responses to FMD vaccine, while maternal antibodies interfered with the induction of humoral responses.
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