Key result
Advanced age in obese women with HF is linked to ~7% lower LVEF versus middle-age.
Cross-Sectional (n=193)
No
Absolute Event Rate: 45.9% vs 53.1%
p-value: p=<0.05
Ageing negatively impacts myocardial functional state, worsening both systolic and diastolic function in women with CHF and overweight/obesity.
Age-related myocardial changes in women with CHF and obesity remain hypothesis-generating; larger prospective studies needed before clinical consideration.
Women are near 50 % of all patients with chronic heart failure (CHF). Next few years the CHF in women will reach 8 %, and in men only 3 %. In 40 years old the risk of CHF without old myocardium infraction is 1/6 in women and 1/9 in men. The aim of the work was the study of age-related changes of systolic and diastolic function of myocardium at CHF in women with overweight and obesity.Methods: there were examined 193 women of the different age groups with CHF of I-III functional class on the background of the normal, redundant body mass and abdominal obesity of I-III degree. The indices of systolic and diastolic function of myocardium were assessed by the method of echocardiography. Processing of the received data was carried out by the methods of non-parametric statistics.Results. There was established that with age in women with overweight and obesity takes place the progression of CHF that is demonstrated by the raise of the functional class of disease, lowering of the systolic function of myocardium, formation and progression of the pulmonary hypertension. There takes place I type of the diastolic dysfunction that is more evident in studied women of the senile age group.Conclusion: There was demonstrated the negative influence of an ageing on the functional state of myocardium at CHF in women with overweight and obesity
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Петро Петрович Бідзіля (2015) conducted a cross-sectional in Chronic heart failure with overweight and obesity (n=193). Advanced age (75-89 years) vs. Middle age (45-59 years) was evaluated on Left ventricular ejection fraction (LVEF) (p=<0.05). Advanced age (75-89 years) in women with chronic heart failure and obesity was associated with a significant decrease in left ventricular ejection fraction to 45.9% compared to 53.1% in middle-aged women (45-59 years).
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