Key result
In women with chronic heart failure, increasing body mass index is associated with progressive dilatation of the aorta, left ventricle, and right atrium, along with increased concentric hypertrophy.
Why the study?
Does increased body mass index correlate with worse echocardiographic structural and functional changes in women with chronic heart failure?
Observational (n=237)
No
Does increased body mass index correlate with worse echocardiographic structural and functional changes in women with chronic heart failure?
Higher BMI in women with chronic heart failure is associated with more pronounced adverse cardiac remodeling, including concentric hypertrophy and diastolic dysfunction.
Higher BMI may link to adverse remodeling in women with HF; hypothesis-generating and requires longitudinal trials before clinical adoption.
Chronic heart failure (CHF) is a widespread disease of cardiovascular system its prevalence is caused with improvement of diagnostic methods simultaneously with an aging of general population. Women are the half of all patients with CHF most of them has preserved fraction of output from the left ventricle with associated diastolic dysfunction. The aim of research was the study of echocardiographic changes in women with chronic heart failure depending on body weight index.Methods: There were examined 237 women with different body weight index (BWI), in 222 was diagnosed CHF of 1-111 functional class (FC). All patients underwent calculation of BWI using Ketle formula and Doppler-echocardiographic examination. The calculations of results were carried out using the methods of parametric and nonparametric statistics depending on size and distribution of samples.Results: In women with CHF the growth of dilatation of aorta, right atrium and left ventricle take place at an increase of BWI. The maximal size of the left atrium and right ventricle were registered in the group of examined person with normal body weight. The hypertrophy of left ventricle myocardium in women with CHF progresses proportionally to an increase of BWI. In patients with CHF on the background of obesity the deeper processes of valvular calcination take place. There were not observed the reliable differences between the main groups in the prevalence of systolic dysfunction but there takes place a tendency to its predominance in examined persons with normal body weight. In women with CHF with an increase of BWI takes place the deepening of diastolic dysfunction (by the type of relaxation disorder) and an increase of its prevalence. The remodeling of myocardium in women with CHF in most cases was presented by concentric hypertrophy of the left ventricle and its frequency is directly proportional to an increase of BWI.Conclusions: There were established that with an increase of BWI in women with CHF the dilatation of aorta, left ventricle and right atrium, hypertrophy of myocardium and valvular calcification are more intense. There was observed a tendency to predominance of the systolic dysfunction in women with CHF and normal body weight. The prevalence and heaviness of diastolic dysfunction by the type of relaxation disorder of the left ventricle grows up proportionally to an increase of BWI. Remodeling of myocardium in most cases is represented by concentric hypertrophy of LV and its frequency rises with an increase of BWI
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Петро Петрович Бідзіля (2015) conducted an observational in Chronic heart failure (n=237). Higher Body Mass Index (Overweight and Obesity) vs. Normal Body Mass Index was evaluated on Echocardiographic structural and functional changes. In women with chronic heart failure, increasing body mass index is associated with progressive dilatation of the aorta, left ventricle, and right atrium, along with increased concentric hypertrophy.
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